melphalan
composé chimique
se yon
type d'entité chimique
sou-klas
D/L-sarcolysin[14]
itilizasyon
médicament
structure chimique
masse
304,074533 unité de masse atomique unifiée[25]
stéréoisomère de
D-sarcolysine[26]
formule chimique
C₁₃H₁₈Cl₂N₂O₂[5]
SMILES canonique
C1=CC(=CC=C1CC(C(=O)O)N)N(CCCl)CCCl[5]
SMILES isomérique
C1=CC(=CC=C1C[C@@H](C(=O)O)N)N(CCCl)CCCl[5]
maladie traitée
myélome multiple[30]
cancer du sein[30]
rhabdomyosarcome[30]
neuroblastome[30]
amylose[31]
prédisposition génétique au neuroblastome[31]
statut légal (médicament)
avertissement encadré[32]
rôle du sujet
Agent alkylant[33]
agent alkylant antinéoplasique[34]
myeloablative agonists[34]
cancérogène[35]
catégorie Commons
Melphalan
Referans
- ↑ 1,0 1,1 1,2 1,3 1,4 et 1,5 Global Substance Registration System, 19 novanm 2016, angle, melphalan, Q41OR9510P
- ↑ CAS Common Chemistry, 10 avril 2021, https://commonchemistry.cas.org/detail?cas_rn=148-82-3, SGDBTWWWUNNDEQ-LBPRGKRZSA-N
- ↑ California Proposition 65 list of chemicals, 6 janvye 2020, https://oehha.ca.gov/chemicals/melphalan
- ↑ 4,0 4,1 et 4,2 ChEBI, 3 oktòb 2016, angle, melphalan, 28876
- ↑ 5,0 5,1 5,2 5,3 5,4 et 5,5 PubChem, 19 novanm 2016, angle, 460612, melphalan
- ↑ 6,0 6,1 6,2 6,3 6,4 6,5 et 6,6 SGDBTWWWUNNDEQ-LBPRGKRZSA-N, InChIKey
- ↑ Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard
- ↑ DrugBank, angle, 17 novanm 2015, 01042, Melphalan
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 19 novanm 2016, angle, 7620, melphalan
- ↑ OpenAlex, 26 janvye 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
- ↑ 11,0 et 11,1 ChEMBL, 19 novanm 2016, angle, MELPHALAN, CHEMBL852
- ↑ https://mednet-communities.net/inn/db/ViewINN.aspx?i=745
- ↑ ChEBI release 2020-09-01
- ↑ 14,0 14,1 et 14,2 inferred from InChIKey
- ↑ InChI=1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)/t12-/m0/s1, International Chemical Identifier
- ↑ Immune Epitope Database and Analysis Resource, 1 mas 2022, 141802
- ↑ https://list.essentialmeds.org/medicines/556, eEML - Electronic Essential Medicines List, 23 oktòb 2021
- ↑ Store norske leksikon, 30 me 2020
- ↑ base de données InfoCard de l'ECHA, 27 desanm 2018, 100.005.207, Melphalan, CAS no.: 148-82-3
- ↑ ChemSpider, 19 novanm 2016, angle, 405297, melphalan
- ↑ GF WordNet
- ↑ UniChem
- ↑ sauvegarde de la base de données Freebase, 28 oktòb 2013
- ↑ Hazardous Substances Data Bank, 10 me 2021, 28 oktòb 2019, Melphalan, 3234
- ↑ PubChem, 3 oktòb 2016, angle, 460612, melphalan
- ↑ inferred from InChI
- ↑ RxNorm, 151325, 14 fevriye 2018
- ↑ RxNorm, 1745086, 14 fevriye 2018
- ↑ Recommended INN: List 4, 1962
- ↑ 30,0 30,1 30,2 30,3 et 30,4 N0000147066, 13 desanm 2016, angle, NDF-RT
- ↑ 31,0 et 31,1 Drug Indications Extracted from FAERS, 2 oktòb 2018
- ↑ FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links., https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802
- ↑ N0000147066, 5 mas 2018, NDF-RT
- ↑ 34,0 et 34,1 Medical Subject Headings, 15 mas 2018, D008558
- ↑ 35,0 et 35,1 California Proposition 65 list of chemicals, 18 mas 2020, https://oehha.ca.gov/chemicals/melphalan