CXCR4
protéine
pati de
CXC chemokine receptor 4/atypical chemokine receptor 2[11]
récepteurs couplés aux protéines G[12]
GPCR, rhodopsin-like, 7TM, protein family[13]
CXC chemokine receptor 4 N-terminal domain, protein family[13]
trouvé dans le taxon
codé par
CXCR4[10]
fonction moléculaire
composant cellulaire
processus biologique
positive regulation of cytosolic calcium ion concentration[68][39]
méthode de détermination: IBA, TAS
detection of temperature stimulus involved in sensory perception of pain[43]
méthode de détermination: IEA
detection of mechanical stimulus involved in sensory perception of pain[43]
méthode de détermination: IEA
interagit physiquement avec
image du Gene Atlas
correspondance exacte
catégorie Commons
CXCR4 receptors
Referans
- ↑ sauvegarde de la base de données Freebase, 28 oktòb 2013
- ↑ 2,0 2,1 2,2 2,3 et 2,4 NCBI Gene, 30 me 2020, 7852
- ↑ TCDB, 13 mas 2020
- ↑ TCDB, 29 avril 2020
- ↑ UMLS 2023, 25 me 2023, inferred by common MeSH mappings on source and on Wikidata
- ↑ Ensembl Release 99, ENSP00000386884
- ↑ Ensembl Release 99, ENSP00000241393
- ↑ 8,00 8,01 8,02 8,03 8,04 8,05 8,06 8,07 8,08 et 8,09 P61073, 9 out 2016, UniProt, angle
- ↑ OpenAlex, 26 janvye 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
- ↑ 10,0 10,1 10,2 et 10,3 UniProt, 13 novanm 2019, P61073
- ↑ 11,0 11,1 et 11,2 InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P61073
- ↑ 9.A.14.13.17, 2 oktòb 2019, hierarchical database ID heuristic
- ↑ 13,0 et 13,1 inferred from protein domain or family
- ↑ 14,0 14,1 14,2 14,3 14,4 et 14,5 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, InterPro, GOA
- ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Proteome Inc., Engagement of CD28 modulates CXC chemokine receptor 4 surface expression in both resting and CD3-stimulated CD4+ T cells, GOA
- ↑ 16,00 16,01 16,02 16,03 16,04 16,05 16,06 16,07 16,08 16,09 16,10 16,11 et 16,12 IEA, 8 avril 2019, P61073, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ IEA, 31 oktòb 2017, P61073, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61073&geneProductId=UniProtKB:P61073, UniProt
- ↑ IPI, 8 avril 2019, P61073, beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ IPI, 8 avril 2019, P61073, Cutting edge: association of the motor protein nonmuscle myosin heavy chain-IIA with the C terminus of the chemokine receptor CXCR4 in T lymphocytes, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ IPI, 8 avril 2019, P61073, RING finger protein 113A regulates C-X-C chemokine receptor type 4 stability and signaling, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ IPI, 8 avril 2019, P61073, Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ IPI, 8 avril 2019, P61073, Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, IntAct protein interaction database, Actin-binding protein drebrin regulates HIV-1-triggered actin polymerization and viral infection, GOA
- ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, IntAct protein interaction database, Pancreatic adenocarcinoma upregulated factor promotes metastasis by regulating TLR/CXCR4 activation, GOA
- ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, IntAct protein interaction database, CXCR4-CCR5: a couple modulating T cell functions, GOA
- ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, IntAct protein interaction database, Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5, GOA
- ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, IntAct protein interaction database, Cutting edge: association of the motor protein nonmuscle myosin heavy chain-IIA with the C terminus of the chemokine receptor CXCR4 in T lymphocytes, GOA
- ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, IntAct protein interaction database, A functional heteromeric MIF receptor formed by CD74 and CXCR4, GOA
- ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, IntAct protein interaction database, Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function, GOA
- ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, IntAct protein interaction database, Constitutive association of cell surface CCR5 and CXCR4 in the presence of CD4, GOA
- ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, IntAct protein interaction database, F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse, GOA
- ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, IntAct protein interaction database, CD164 regulates the tumorigenesis of ovarian surface epithelial cells through the SDF-1α/CXCR4 axis, GOA
- ↑ 33,0 33,1 et 33,2 IDA, 8 avril 2019, P61073, Cutting edge: association of the motor protein nonmuscle myosin heavy chain-IIA with the C terminus of the chemokine receptor CXCR4 in T lymphocytes, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ IPI, 8 avril 2019, P61073, The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ 35,0 et 35,1 TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Proteome Inc., Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes, GOA
- ↑ NAS, 1 janvye 2018, P61073, Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ IDA, 8 avril 2019, P61073, CXC chemokine receptor 4 is a cell surface receptor for extracellular ubiquitin, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61073&geneProductId=UniProtKB:P61073, 31 oktòb 2017, Critical Assessment of Protein Function Annotation, Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine, GOA
- ↑ 39,00 39,01 39,02 39,03 39,04 39,05 39,06 39,07 39,08 39,09 et 39,10 IBA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, GO Central, Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium, GOA
- ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Critical Assessment of Protein Function Annotation, Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine, GOA
- ↑ 41,0 et 41,1 IDA, 8 avril 2019, P61073, RING finger protein 113A regulates C-X-C chemokine receptor type 4 stability and signaling, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ NAS, 8 avril 2019, P61073, Genomic organization and functional characterization of the chemokine receptor CXCR4, a major entry co-receptor for human immunodeficiency virus type 1, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ 43,00 43,01 43,02 43,03 43,04 43,05 43,06 43,07 43,08 43,09 43,10 43,11 43,12 43,13 43,14 43,15 43,16 43,17 43,18 43,19 43,20 43,21 43,22 43,23 43,24 43,25 43,26 43,27 et 43,28 IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Ensembl, GOA
- ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 1 janvye 2018, Proteome Inc., Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS, GOA
- ↑ 45,0 et 45,1 IDA, 8 avril 2019, P61073, Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ 46,0 et 46,1 IDA, 8 avril 2019, P61073, Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ 47,0 et 47,1 IDA, 8 avril 2019, P61073, beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ IDA, 8 avril 2019, P61073, CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Mouse Genome Informatics, CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration, GOA
- ↑ IDA, 31 oktòb 2017, P61073, MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61073&geneProductId=UniProtKB:P61073, UniProt
- ↑ 51,0 et 51,1 IDA, 8 avril 2019, P61073, The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ 52,0 52,1 52,2 52,3 et 52,4 IDA, 8 avril 2019, P61073, Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ 53,0 53,1 53,2 et 53,3 TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Reactome, GOA
- ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Proteome Inc., Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors, GOA
- ↑ IMP, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Critical Assessment of Protein Function Annotation, Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine, GOA
- ↑ HDA, 8 avril 2019, P61073, MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Proteome Inc., Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS, GOA
- ↑ 58,0 et 58,1 ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, British Heart Foundation, GOA
- ↑ IEP, 8 avril 2019, P61073, Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic study, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61073&geneProductId=UniProtKB:P61073, 31 oktòb 2017, Proteome Inc., Down-regulation of CXCR4 by human herpesvirus 6 (HHV-6) and HHV-7, GOA
- ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61073&geneProductId=UniProtKB:P61073, 31 oktòb 2017, Gene Ontology Consortium, GOA
- ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Proteome Inc., Use of chemokine receptors by poxviruses, GOA
- ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, British Heart Foundation, The multiple personalities of the chemokine receptor CCR7 in dendritic cells, GOA
- ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61073&geneProductId=UniProtKB:P61073, 31 oktòb 2017, InterPro, GOA
- ↑ IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P61073&geneProductId=UniProtKB:P61073, 31 oktòb 2017, Mouse Genome Informatics, Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines, GOA
- ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Proteome Inc., HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases, GOA
- ↑ IMP, 1 janvye 2018, P61073, Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Proteome Inc., Down-regulation of CXCR4 by human herpesvirus 6 (HHV-6) and HHV-7, GOA
- ↑ IMP, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, Mouse Genome Informatics, Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines, GOA
- ↑ IBA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 1 janvye 2018, GO Central, Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium, GOA
- ↑ IMP, 8 avril 2019, P61073, The WHIM-like CXCR4(S338X) somatic mutation activates AKT and ERK, and promotes resistance to ibrutinib and other agents used in the treatment of Waldenstrom's Macroglobulinemia., GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, 8 avril 2019, YuBioLab, Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet-induced obesity, GOA
- ↑ IDA, 8 avril 2019, P61073, Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4., GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ IMP, 8 avril 2019, P61073, Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61073, UniProt
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, 17 out 2016, 844, angle
- ↑ Open Targets Platform, 14 out 2023, https://platform.opentargets.org/drug/CHEMBL518924
- ↑ Identifiers.org